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Evaluation of a psychosocial intervention program for patients with multiple sclerosis |
| Auteur: |
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Mariëlle Visschedijk |
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€ 25,95 incl. BTW |
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HIV-1 Superinfection in homosexual men |
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Dr. Andrea Rachinger |
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€ 12,95 incl. 6% BTW |
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Sense and sensitivity of summary measures of health |
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M.F. Janssen |
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Summary measures of health combine information on quantity of life and quality of life into a single metric, which makes them a powerful tool to describe, monitor and compare health or health interventions. The Quality Adjusted Life Year (QALY) and the Disability Adjusted Life Year (DALY) are the most widely used summary measures of health, mainly in economic evaluations (cost-utility analysis) and for assessing population health respectively. Although the QALY and DALY in their standard operationalization have gained popularity over the last few decades, there are still numerous methodological challenges. |
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€ 34,95 incl. 6% BTW |
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The transmission and segregation of mitochondrial DNA mutations |
| Auteur: |
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Lorraine Jacobs |
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Mitochondrial encephalomyopathies are disorders associated with abnormalities of the
terminal component of mitochondrial energy metabolism, i.e. oxidative phosphorylation
(OXPHOS). Recent epidemiological studies have shown that ~1 in 8000 of the general
population have an OXPHOS disorder. OXPHOS related diseases therefore cause significant
morbidity and mortality. OXPHOS disease can be due to mutations in mitochondrial DNA
(mtDNA) or nuclear DNA genes. The main topic of this thesis is to define the somatic
segregation and familial transmission and, as well, the origin of heteroplasmic mutations in
the mtDNA. This is related to their clinical expression and possible modifying factors. |
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€ 34,95 incl. 6% BTW |
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